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H5N1 infuenza vaccine immunization consists of two intramuscular injections, given approximately one month apart. The vaccine has been purchased by the federal government for inclusion within the National Stockpile for distribution by public health offcials if needed. The study showed that 5 percent of individuals who received the 0 microgram, two-dose regimen developed antibodies at a level that is expected to reduce the risk of getting infuenza. Although the level of antibodies seen in the remaining individuals did not reach that level, current scientifc information on other infuenza vaccines suggests that less than optimal antibody levels may still have the potential to help reduce disease severity and infuenza-related hospitalizations and deaths.

National Institutes of Health and other government agencies and manufacturers are working to develop a next generation of infuenza vaccines for enhanced immune responses at lower doses, using technologies intended to boost the immune response. Meanwhile, the approval and availability of this vaccine will enhance national readiness and the nations ability to protect those at increased risk of exposure.

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